Black Pepper Extract 98% Piperine
[Active ingredient]: Piperine
[IUPAC Name]: 1-[5-(1, 3-benzodioxol- 5-yl)-1-oxo-2, 4-pentadienyl]piperidine
[Other Names]: 5-(3, 4-methylenedioxyphenyl)-2, 4-pentadienoyl-2-piperidine piperoylpiperidine
[Molecular Formula]: C17H19NO3
[Molecular Weight]: 285.34
[Molar Mass]: 285.34 g mol − 1
[Density]: 1.193 g/cm3
[Certification of Analysis]:
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Name
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Black Pepper Extract Powder
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Botanical Source
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Piper nigrum L.
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Maker Compounds
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95% Piperine
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Molecular Formula
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C17H19NO3
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Molecular Weight
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285.34
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Test Method
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HPLC
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Color
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Yellowish-white
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Part Used
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Stem or Root
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Appearance
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Crystal
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Ash Content
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≤5%
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Extract solvent
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Ethanol & Water
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Drying Method
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Spray Dying
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Particle Size
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NLT100%Through 80 mesh
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Loss on Drying
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≤ 5.0%
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Bulk Density
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40-60g/100ml
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Arsenic
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≤2ppm
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Lead
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≤2ppm
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Total Plate Count
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≤1000cfu/g
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Total Yeast & Mold
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≤100cfu/g
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[Preparation]:
Piperine is commercially available. If desired, it may be extracted from black pepper using dichloromethane. The amount of piperine varies from 1-2% in long pepper, to 5-9% in the white and the black peppers of commerce. Further, it may be prepared by treating the solvent-free residue from an alcoholic extract of black pepper, with a solution of sodium hydroxide to remove resin (said to contain chavicine, an isomer of piperine) and solution of the washed, insoluble residue in warm alcohol, from which the alkaloid crystallizes on cooling.
[Application]:
1.As pharmaceutical raw materials for arthritis, rheumatism, anti-inflammation, detumescence and so on, it is mainly used in pharmaceutical field;
2.As products effective ingredients for improving blood circulation and soothing the nerves, it is mainly used in health product industry;
3.As active ingredients of skin care products, it is mainly used in cosmetic industry.
[Main Function]:
Piperine is the alkaloid responsible for the pungency of black pepper and long pepper, along with chavicine (an isomer of piperine). It has also been used in some forms of traditional medicine and as an insecticide. Piperine forms monoclinic needles, is slightly soluble in water and more so in alcohol, ether or chloroform: the solution in alcohol has a pepper-like taste.
Piperine has also been found to inhibit human CYP3A4 and P-glycoprotein, enzymes important for the metabolism and transport of xenobiotics and metabolites.In animal studies, piperine also inhibited other enzymes important in drug metabolism. By inhibiting drug metabolism, piperine may increase the bioavailability of various compounds and alter the effectiveness of some medications. Notably, piperine may enhance bioavailability of curcumin by 2000% in humans.
[Storage Situation]: Stored in a cool and dry well-closed container kept away from moisture and strong light or high temperature
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