Trimethoprim
(TMP)
Other Name: trimethoprim crystalline; 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diyldiamine;Antibiotic synergist
MF: C14H18N4O3
MW: 290.32
CAS No.: 738-70-5
EINECS No.:212-006-2
Appearance: White or yellowish-white powder
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TESTING ITEMS
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SPECIFICATION
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RESULT
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Appearance
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WHITE OR YELLOWISH-WHITE POWDER
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White powder
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Solubility
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Very slightly soluble in water, slightly soluble in alcohol.
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Very slightly soluble in water,
slightly soluble in alcohol.
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A: Melting point
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199-203°C
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200.0-202.7°C
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B:Specific absorbance
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Max.287nm: 240-250
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249
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C: IR-spectrum
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Complies with reference spectrum
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Complies with reference spectrum
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D:Chemical reaction
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Green fluorescence at 365nm
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Green fluorescence at 365nm
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Appearance of solution
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Not more intensely colored than Reference Solution BY7
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Less intensely colored than reference solution BY7
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Related substances Method A by HPLC:
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Impurity F
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≤0.1%
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0.05%
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Any single impurity
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≤0.1%
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less than 0.1%
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Total impurities
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≤0.2%
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less than 0.2%
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Related substances Method B by HPLC:
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Any single impurity
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not more than 0.1%
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less than 0.1%
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Total impurities
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not more than 0.2%
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less than 0.2%
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Heavy metals
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not more than 20PPM
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less than 20ppm
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RESIDUAL METHANOL
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not more than 3000PPM
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NOT DETECTED
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Residual DMSO
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not more than 5000PPM
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NOT DETECTED
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Residual acetic acid
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not more than 5000PPM
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NOT DETECTED
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Impurity K(aniline) by GC
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not more than 5PPM
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NOT DETECTED
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LOSS ON DRYING
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not more than 1.0%
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0.33%
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SULPHATED ASH
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not more than 0.1%
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0.05%
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ASSAY
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98.5-101.0%
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99.89%
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Usage: Trimethoprim is antibacterial, its antibacterial function is like sulfonamide, which will be better when used together with sulfonamide. It is used to cure breath-path infection, senile chronic bronchitis, bacillary dysentery, urinarytract infection, nephritis, enteritis typhoid , gonorrhea and some specific inflammation.
Packing is 25kg/drum
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