DL-Mandelic Acid Application
Mandelic acid use alone or in tandem with antioxidant vitamins, have multiple beneficial effects as a skin treatment—including antibacterial effects and improvement in photoaged skin, acne, abnormal pigmentation, and skin texture. Safe use in darkly pigmented skin types was also a major difference seen when the mandelic acid products were compared with glycolic acid and tretinoin.
Mandelic acid, an alpha-hydroxy acid (AHA) derived from the hydrolysis of an extract of bitter almonds has been used in treating common skin problems such as photoaging, irregular pigmentation, and acne. mandelic acid is useful in suppressing pigmentation, treating inflammatory noncystic acne, and rejuvenating photoaged skin.which is useful in preparing the skin for laser peeling and in helping the skin heal after laser surgery.
Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid with the chemical formula HOCH(C6H5)COOH and structure:
The mandelic acid molecule is larger than the glycolic acid molecule, a widely used AHA. In addition, mandelic acid, which has a pK of 3.41, is stronger than glycolic acid, which has a pK of 3.83 at 25oC. The acidity of AHAs may vary considerably with changes in temperature. Mandelic acid has a high melting point, is partially soluble in water, and is freely soluble in isopropyi and ethyl alcohol.Mandelic acid occurs in two enantiomeric forms that may affect pharmaceutical activity.
Fig. 1: Melasma in 45-year-old female (left) with hyperpigmen-tation caused by glycolic acid plus hydroquinone, and same patient (right) 9 months after use of mandelic acid BID.
Medical Uses
Mandelic acid has been used in medicine for many years as a urinary antiseptic. Methenamine mandelate (Mandelamine, Parke-Davis, Morris Plains, NJ) has the urinary antiseptic action of both methenamine and mandelic acid. In concentrations of 35g to 50g/100L of urine, it inhibits Staphylococcus aureus, bacillus proteus, escherichia coli, and aerobacter aerogenes .Chemically, mandelic acid has a structure similar to that of other well-known antibiotics. It is a nontoxic substance that, after being ingested orally, is excreted in the urine.
Product Specification;
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Appearance
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White crystalline powder
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Solubility
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Soluble in water, diethyl ether, ethanol and isopropanol
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Identification
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A.The IR spectrum of sample should be identical with that of reference standard;
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B.The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.
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Melting Point
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118°C～121°C
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Cl-
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≤0.01%
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Heavy Metal
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≤10 ppm
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Residue on Ignition
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≤0.1%
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Loss on Drying
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≤0.5%
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Content
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≥99.00% (dried substance)
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Storage
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Preserve in well-closed, light-resistant containers.
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Company Profile
Shaanxi Top Pharm Chemical Co., Ltd. is located in Chemical Industrial Zone in Hantai County, Shaanxi Province. This Industrial Zone, as a provincial chemical zone authorized by China People's Government, is situated at the foot of a hill and beside a river, showing distinctive geographic advantages. The company covers an area of 98000 square meters, including a building area of 32000 square meters. In addition to being equipped with consummated production and supporting facilities, the company has also been built with a new product R&D center. This has provided powerful technological support and driven forces to health development of the company.
With the philosophy of "creativity, Excellency and development", the company is committed to seek for in-depth development based on new product technology and excellent quality. In the future the company will reinforce its service sense to both new and old customers, offering thoughtful services while providing high-quality products. Our advancement and development cannot be separated with the great support of all customers.
Under the direction of the strategy of technological innovation and with the goal of developing biochemical engineering, our company has successfully developed multiple biotechnologies concerning chiral compound synthesis using biological enzyme as catalyzer. Products such as chiral mandelic acid series, chiral cyanohydrins series, intermediate and diphenylacetonitrile like atorvastatin are our hot-sale products with advantaged competitiveness all over the world. In the future, the company will further enhance its service, offer better products at competitive prices and quality service. At the same time, we highly appreciate the supports and help from all our customers. Let's cooperate together hand in hand and create a win-win situation as well as a bright future.
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