ESMOLOL HYDROCHLORIDE
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PRODUCT IDENTIFICATION
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CAS NO.
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81147-92-4; 84057-94-3; 103598-03-4 (Base)
81161-17-3 (Hydrochloride)
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EINECS NO.
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FORMULA
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C16H25NO4·HCl
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MOL WT.
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331.8
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H.S. CODE
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TOXICITY
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SYNONYMS
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Brevibloc; Esmolol HCl;
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(±)-Methyl-p-[2-hydroxy- 3-(isopropylamino)propoxy] hydrocinnamate; 4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)phenylpropionic acid, methyl ester; Methyl 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)benzenepropanoate;
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CLASSIFICATION
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PHYSICAL AND CHEMICAL PROPERTIES
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PHYSICAL STATE
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white to off-white crystalline powder
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STABILITY
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Stable under ordinary conditions.
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APPLICATIONS
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Esmolol is a short-term (half-life: apprx. 9 minutes) cardioselective beta1-blocking agent used as an antiarrhythmic in the control of atrial fibrillation, atrial flutter, and noncompensatory sinus tachycardia. Its chemical designation is (±)-Methyl-p-[2-hydroxy- 3-(isopropylamino)propoxy] hydrocinnamate; existing enantiomeric pair. The hydrochloride salt of esmolol a white to off-white crystalline powder; soluble in water and alcohol; administered by intravenous infusion; administered by intravenous infusion.
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SALES SPECIFICATION (USP24)
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APPEARANCE
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white to off-white crystalline powder
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ASSAY
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98.5% - 101.5%
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WATER
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2.0% max
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INDIVIDUAL IMPURITY
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0.2% max (TOTAL 0.5% max)
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SOLVENT RESIDUE
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0.1% max
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HEAVY METALS
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20ppm max
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