|
ESMOLOL HYDROCHLORIDE
|
|
PRODUCT IDENTIFICATION
|
|
CAS NO.
|
81147-92-4; 84057-94-3; 103598-03-4 (Base)
81161-17-3 (Hydrochloride)
|
|
|
EINECS NO.
|
|
|
FORMULA
|
C16H25NO4·HCl
|
|
MOL WT.
|
331.8
|
|
H.S. CODE
|
|
|
TOXICITY
|
|
|
SYNONYMS
|
Brevibloc; Esmolol HCl;
|
|
(±)-Methyl-p-[2-hydroxy- 3-(isopropylamino)propoxy] hydrocinnamate; 4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)phenylpropionic acid, methyl ester; Methyl 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)benzenepropanoate;
|
|
CLASSIFICATION
|
|
|
PHYSICAL AND CHEMICAL PROPERTIES
|
|
PHYSICAL STATE
|
white to off-white crystalline powder
|
|
STABILITY
|
Stable under ordinary conditions.
|
|
APPLICATIONS
|
|
Esmolol is a short-term (half-life: apprx. 9 minutes) cardioselective beta1-blocking agent used as an antiarrhythmic in the control of atrial fibrillation, atrial flutter, and noncompensatory sinus tachycardia. Its chemical designation is (±)-Methyl-p-[2-hydroxy- 3-(isopropylamino)propoxy] hydrocinnamate; existing enantiomeric pair. The hydrochloride salt of esmolol a white to off-white crystalline powder; soluble in water and alcohol; administered by intravenous infusion; administered by intravenous infusion.
|
|
SALES SPECIFICATION (USP24)
|
|
APPEARANCE
|
white to off-white crystalline powder
|
|
ASSAY
|
98.5% - 101.5%
|
|
WATER
|
2.0% max
|
|
INDIVIDUAL IMPURITY
|
0.2% max (TOTAL 0.5% max)
|
|
SOLVENT RESIDUE
|
0.1% max
|
|
HEAVY METALS
|
20ppm max
|
